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Organic Custom Inquiries

At GFS we make every effort to provide you with a timely and detailed quote for your project. There are many factors that must be considered.


You will be contacted directly to clarify your project needs. GFS will provide a primary contact for all of your communications but the entire team will be briefed and will be familiar with your project.

The R&D team will meet with the operations team to review your requirements.






Your inquiry is important to us. Here is what to expect when submitting a quote for a custom organic:

 R&D will review preps and methods to determine the most economical route for manufacturing and scale-up to meet your specific requirements.


 If required, purchasing will begin sourcing to identify your raw materials and to get the most up to date pricing information.





 If your project fits in with our core technology expertise, we will quote your project and will provide a price and project schedule/timeline. You can trust GFS when we tell you that we can deliver your products. We are careful to select projects that match our core competencies. Many of our team members have between twenty and forty years of experience with your type of chemistry.


 The operations group will review the production schedule and available equipment options.


A formal quote will be sent to you for review. All GFS quote estimates are for a specific period of time. Expired quotes will be re-evaluated if you go past the date to determine project scheduling. Lead times can vary significantly based on the mix of products in production. To ensure your scheduling, please provide us with a realistic timeline for when you require the materials so that we can meet your deadlines. We are happy to provide you with a budgetary quote but production times will need to be confirmed at the time a purchase order is placed.


   For inquiries, e-mail or call 740-881-5440 extension 355.

GFS Chemicals is a full service partner and specialty chemical manufacturer in the development of reagents and catalysts that you need in order to fully leverage your chemical development and processing operations. We are capable of supporting businesses on bulk/pilot/research scales.

 GFS has become the leader in the development and production with the widest range of acetylenic, olefinic and silyl intermediates.  GFS is the dominant manufacturer, offering over 2/3 of the 600 acetylenic compounds available today. That is over twice the number offered by any other supplier.


 We offer an extensive line of silyl-intermediates, triflates, and many other core organic products available in research or bulk.


 Our staff has decades of technical expertise in acetylene, olefin, Grignard, and liquid ammonia chemistries.


 Total GFS manufacturing capacity exceeds 100,000 liters for the combined production of specialty chemicals. GFS is ISO-9001:2008 certified.



The heart of our organic chemical manufacturing is a 14,000 square foot, indoor, state-of-the-art product facility in Columbus, Ohio - open since 2000. This new chemical plant demonstrates GFS Chemicals' investment to specialty organic chemicals.


  Batch Unit Operations

Batch unit operations include: batch reactions; non-reactive mixing; extraction; filtration; centrifugation; crystallization and drying (tray and rotary vacuum); distillation and stripping; and sublimation (kilo lab scale).

Bulk Chemical Handling

We are capable of handling these bulk chemicals: anhydrous liquid ammonia; destabilized acetylene; sodium/lithium and corresponding amides; bromine; iodine; ethylene oxide; thionyl chloride; sulfuryl chloride; chlorosulfonic acid; hydrogen sulfide; sodium cyanide; liquid nitrogen; carbon disulfide trimethylchlorosilane and organosilanes.

 Core Competencies



  1. Acetylene chemistry
  2. Propargylic amines
  3. Custom Grignard chemistry
  4. Specialty halides
  5. Si blocked compounds
  6. Birch reductions
  7. Alpha/omega functionalization
  8. Bromine Chemistry

Unit Operations Supported

  1. Distillation
    1. Stripping
    2. Rectification
    3. Wiped film distillation
    4. Atmospheric pressure to ~ 1 mm Hg vacuum
  2. Crystallization
  3. Centrifugation
  4. Filtration
  5. Extraction
  6. Drying (vacuum to atmospheric)
    1. Rotary
    2. Tray

Core Organic Product Lines


  1. Alkynes
    1. Terminal & internal bond positions
    2. Diynoic acids, alkynols, halo-alkynes
  2. Specialty olefins
    1. Dienes, ene-ynes, α,ω halo-olefins
    2. Pure cis and trans isomers
  3. Insect pheromones
  4. Grignard reagents
  5. Specialty halides
    1. Bromides
    2. Chlorides
    3. Iodides
    4. Halo-hydrins
  6. Bipyridines & phenanthrolines
  7. Phenanthrolines
  8. Terpyridines

Organic Reaction Expertise

  1. Acetylide coupling
  2. Alkylation
  3. Amidation
  4. Amination
  5. Birch Reduction
  6. Bromination
  7. Chlorination
  8. Dehydrohalogenation
  9. Dissolving metal reductions (Li, Na)
  10. Friedel-Crafts reaction
  11. Gabriel synthesis
  12. Grignard (preparation and use)
  13. Iodination
  14. Low P hydrogenation
  15. Skraup reaction
  16. Sonogashira coupling
  17. Stille coupling
  18. Suzuki coupling
      New Technologies
  19. Thiophenes
  20. Bridged orthoesters
      Hazardous Materials Handled
  21. Acetylene
  22. Acrolein
  23. Allyl halides
  24. Ammonia (liquid)
  25. Bromine
  26. Butyllithium
  27. Carbon disulphide
  28. Chloroformates
  29. Chlorosulfonic acid
  30. Epichlorohydrin
  31. Ethylene oxide
  32. Hydrogen bromide
  33. Hydrogen chloride
  34. Iodine
  35. Lithium
  36. Lithium amide
  37. Methyl bromide
  38. Methyl iodide
  39. Organolithium compounds
  40. Red phosphorus
  41. Phosphorous halides
  42. Sodamide
  43. Sodium
  44. Sulphur dioxide
  45. Thionyl chloride