The total GFS manufacturing capacity exceeds 100,000 liters for the combined production of inorganic and organic specialty chemicals; more than 80 years of experience are at your disposal.

We are not presently certified for cGMP manufacturing; however, we carefully follow ISO-9001:2000 guidelines and manufacture a wide range of precursor materials that facilitate the synthesis of various pharmaceutical ingredients.

General
The organic chemical manufacturing capabilities of GFS Chemicals reside in a 14,000 square foot, state-of-the-art, indoor production facility. This new facility demonstrates GFS Chemicals' long term commitment to the specialty organic chemical business, in which it has been engaged since the 1940's. GFS Chemicals has retained ISO 9001:2000 certification since 1997. Reaction temperature handling from –60^o to 140^oC, and pressure from full vacuum to 150 psi.

Types of Chemistry Performed
Liquid ammonia/alkali metal chemistry for the production of alkynes (acetylenes) and olefins; Halogenation/Dehydrohalogenation; Grignard chemistry; Alkylation; Amination; Bromination, Chlorination, Birch reductions, Esterification; Epoxidation; Skraup quinoline syntheses; Low pressure hydrogenation; other.

Batch Unit Operations performed
Include batch reactions; non-reactive mixing; extraction; filtration; centrifugation; crystallization and drying (tray and rotary vacuum); Distillation and stripping; sublimation (kilo lab scale).

Bulk Chemicals Routinely handled
Include anhydrous liquid ammonia; destabilized acetylene; sodium/lithium and corresponding amides; bromine; iodine; ethylene oxide; thionyl chloride; sulfuryl chloride; chlorosulfonic acid; hydrogen sulfide; sodium cyanide; liquid nitrogen; carbon disulfide trimethylchlorosilane and other organosilanes.

Core Product Base
Acetylenics, olefins, silanes, bipyridines, phenanthrolines, other heteroaromatic ligands, Grignards.

Equipment List
Kilo lab: Glassware up to 50LT. Processing is carried out in walk-in lab hoods and benchtop hoods. Distillation columns from 1” x 1' to 2.5” x 6'.

Production Plant
Reactor Capacity
- Glass lined steel: 10, 25, 30, 50, 100, 500 gal, 1000 gal (expansion planned)
- 316L stainless steel: 50 LT; 50 and 200 gal (Pressure to 150psi)
- Hastelloy C: up to 500 gal
- All reactors equipped with 75 psi steam/refrigerated PG/well water (jacket) and well   water/refrigerated PG (condensor)

Distillation Equipment (all capable of full vacuum operation)
- 30 gal glass-lined pot/4” x 4' column w/receiver (column internals: structured glass packing)
- 50 gal glass-lined pot/4” x 8' column w/receiver (column internals: structured glass packing)
- 50 gal glass-lined pot/4” x 10' column w/receiver (column internals: 316L SS random packing)
- 100 gal 316L SS pot/50 theoretical plate (column internals: 316L SS random packing)
- Pope 4” Wiped Film Still w/feed tank & receiver
- 500 gal glass lined pot/ 4”x 4’ column with receiver

Other Plant Equipment
- 30” x 18” Tolhurst basket centrifuge hastelloy
- Glass-lined and 316 SS rotary vacuum dryers (5 cu. ft. - 110 cu. ft)
- 42” x 24” 316 ss Tolhurst basket centrifuge (planned expansion)
- 24” x 12” 316 SS Tolhurst basket centrifuge
- Three Celicote Engineering vent scrubbers (3000 cfm – 9000 cfm) for the removal of sulfide-laden vent streams, chloride/acid gas and ammonia-laden vent streams 
- AGA Gas Cumulus PX-20 heat transfer system for near-cryogenic cooling capability (for stainless steel reactors only)
- Emergency vent and containment system designed by Fauske and Associates
- Bulk acetylene, liquid Nitrogen and anhydrous ammonia storage and handling

QC/Analytical Capabilities: 

 Includes GC (two Hewlett Packard 5890); GC/MS; FT-IR; UV-Vis; Karl Fischer; Melting point; ICP, AAGF, Ion Chromatography

Miscellaneous

Protocols are in place for handling liquified gases, refrigerants, and reactive materials such as acetylene and propargyl compounds, olefins, ethylene oxide, silanes, and most solvents including carbon disulfide. Materials currently outside of our protocols include phosgene, vinyl chloride, and polyaromatic hydrocarbons. We routinely campaign multi-ton quantities of specialty organics in glass-lined, Hastelloy C and stainless steel reactors. Smaller reactors and glassware are used to manufacture the classical GFS organics.

Product separation and purification techniques include custom- built distillation systems, as well as thin film and rotary evaporators. Various centrifuge and drying stations are equipped for the bulk handling of a wide range of organic intermediates and salts of organic acids.

Purity profiles of both raw material and finished goods are maintained through advanced analytical instrumentation that includes GCMass Spectrometry and HPLC methodologies.

Plant/Kilo Lab Reactor Capacity

Main Plant
- 7,000 LT combined reactor volume
- Glass lined steel;   316 SS, HastelloyTM C
 -20° to +150° C
- Up to 150 psig (in 316 SS)
- 10 gal to 500 gal (100 gal expansion planned)

Kilo Lab
- 300 LT combined reactor volume
- Glass; 316 SS
 - -80° to +250°C
 - Up to 50 LT

 For more information, contact development@gfschemicals.com.